Drug interactions
Dutasteride-tamsulosin + Larotrectinib
Severity: Minor
Dutasteride-tamsulosin and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a substrate of CYP3A4 and has been reported to inhibit it weakly in vitro. A clinically meaningful rise in tamsulosin exposure is uncertain and probably small.
What this interaction means in plain words
Dutasteride-tamsulosin and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dutasteride-tamsulosin belongs to Genitourinary; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib; the mechanism is not firmly established.
What to do
No empiric dose change is needed. Watch for dizziness or orthostatic hypotension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Larotrectinib
Frequently asked questions
Can I take Dutasteride-tamsulosin with Larotrectinib?
MediHelp rates the interaction as minor. Dutasteride-tamsulosin and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a substrate of CYP3A4 and has been reported to inhibit it weakly in vitro. A clinically meaningful rise in tamsulosin exposure is uncertain and probably small.
How serious is the interaction between Dutasteride-tamsulosin and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Watch for dizziness or orthostatic hypotension.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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