Drug interactions
Dutasteride-tamsulosin + Lidocaine
Severity: Minor
Dutasteride-tamsulosin and Lidocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lidocaine is metabolized by CYP3A4 and CYP1A2 and is only a weak inhibitor, so any rise in tamsulosin exposure is small. Systemic exposure from topical or local use is minimal, and clinically meaningful effects are unlikely.
What this interaction means in plain words
Dutasteride-tamsulosin and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dutasteride-tamsulosin belongs to Genitourinary; Lidocaine belongs to Cardiovascular.
Why it happens
Possible weak competition for CYP3A4 and CYP2D6 metabolism of tamsulosin.
What to do
No routine action is needed; watch for dizziness if systemic lidocaine is given intravenously.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Frequently asked questions
Can I take Dutasteride-tamsulosin with Lidocaine?
MediHelp rates the interaction as minor. Dutasteride-tamsulosin and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lidocaine is metabolized by CYP3A4 and CYP1A2 and is only a weak inhibitor, so any rise in tamsulosin exposure is small. Systemic exposure from topical or local use is minimal, and clinically meaningful effects are unlikely.
How serious is the interaction between Dutasteride-tamsulosin and Lidocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; watch for dizziness if systemic lidocaine is given intravenously.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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