Drug interactions
Dutasteride-tamsulosin + Methadone
Severity: Moderate
Dutasteride-tamsulosin and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methadone can inhibit CYP2D6 and may raise tamsulosin concentrations. Both drugs can cause hypotension and dizziness, so falls and syncope are a concern.
What this interaction means in plain words
Dutasteride-tamsulosin and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Methadone belongs to Musculoskeletal.
Why it happens
CYP2D6 inhibition by methadone plus additive hypotensive effects.
What to do
Monitor blood pressure and orthostatic symptoms, particularly when starting or titrating either drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Dutasteride-tamsulosin with Methadone?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methadone can inhibit CYP2D6 and may raise tamsulosin concentrations. Both drugs can cause hypotension and dizziness, so falls and syncope are a concern.
How serious is the interaction between Dutasteride-tamsulosin and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, particularly when starting or titrating either drug.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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