Drug interactions
Dutasteride-tamsulosin + Paroxetine
Severity: Major
Dutasteride-tamsulosin and Paroxetine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine is a strong CYP2D6 inhibitor and increases tamsulosin exposure. This raises the risk of orthostatic hypotension, dizziness and syncope.
What this interaction means in plain words
Dutasteride-tamsulosin and Paroxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dutasteride-tamsulosin belongs to Genitourinary; Paroxetine belongs to Central Nervous System.
Why it happens
Strong CYP2D6 inhibition reduces tamsulosin clearance.
What to do
Monitor blood pressure and orthostatic symptoms; consider avoiding the combination or using an alternative antidepressant such as sertraline or escitalopram.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Dutasteride-tamsulosin with Paroxetine?
MediHelp rates the interaction as major. Dutasteride-tamsulosin and Paroxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Paroxetine is a strong CYP2D6 inhibitor and increases tamsulosin exposure. This raises the risk of orthostatic hypotension, dizziness and syncope.
How serious is the interaction between Dutasteride-tamsulosin and Paroxetine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms; consider avoiding the combination or using an alternative antidepressant such as sertraline or escitalopram.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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