Drug interactions
Dutasteride-tamsulosin + Primidone
Severity: Moderate
Dutasteride-tamsulosin and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone, partly through its phenobarbital metabolite, induces CYP3A4 and may reduce tamsulosin and dutasteride exposure. BPH symptom control may worsen.
What this interaction means in plain words
Dutasteride-tamsulosin and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Primidone belongs to Central Nervous System.
Why it happens
CYP3A4 induction accelerates metabolism of tamsulosin and dutasteride.
What to do
Monitor for loss of efficacy and consider an alternative BPH agent if symptoms worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Dutasteride-tamsulosin with Primidone?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone, partly through its phenobarbital metabolite, induces CYP3A4 and may reduce tamsulosin and dutasteride exposure. BPH symptom control may worsen.
How serious is the interaction between Dutasteride-tamsulosin and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of efficacy and consider an alternative BPH agent if symptoms worsen.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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