Drug interactions
Dutasteride-tamsulosin + Pseudoephedrine
Severity: Moderate
Dutasteride-tamsulosin and Pseudoephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pseudoephedrine is a sympathomimetic that can raise blood pressure and heart rate and may counteract tamsulosin's effect on prostatic and bladder neck smooth muscle. It can also worsen urinary retention in men with prostatic enlargement.
What this interaction means in plain words
Dutasteride-tamsulosin and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Pseudoephedrine belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism between alpha-adrenergic agonism and alpha-1 blockade.
What to do
Avoid oral decongestants in men with benign prostatic hyperplasia where possible; monitor urinary symptoms and blood pressure if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Dutasteride-tamsulosin with Pseudoephedrine?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pseudoephedrine is a sympathomimetic that can raise blood pressure and heart rate and may counteract tamsulosin's effect on prostatic and bladder neck smooth muscle. It can also worsen urinary retention in men with prostatic enlargement.
How serious is the interaction between Dutasteride-tamsulosin and Pseudoephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral decongestants in men with benign prostatic hyperplasia where possible; monitor urinary symptoms and blood pressure if used.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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