Drug interactions
Dutasteride-tamsulosin + Quinine
Severity: Moderate
Dutasteride-tamsulosin and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine inhibits CYP2D6 and may raise tamsulosin concentrations. Quinine itself can cause hypotension, so additive dizziness is possible.
What this interaction means in plain words
Dutasteride-tamsulosin and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Quinine belongs to Anti Parasitic.
Why it happens
CYP2D6 inhibition by quinine reduces tamsulosin metabolism.
What to do
Monitor for orthostatic hypotension during short quinine courses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Dutasteride-tamsulosin with Quinine?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine inhibits CYP2D6 and may raise tamsulosin concentrations. Quinine itself can cause hypotension, so additive dizziness is possible.
How serious is the interaction between Dutasteride-tamsulosin and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic hypotension during short quinine courses.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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