Drug interactions
Duvelisib + Erythromycin
Severity: Moderate
Duvelisib and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib is a CYP3A4 inhibitor and may increase erythromycin exposure, while erythromycin may in turn raise duvelisib levels through CYP3A4 and P-gp inhibition. Both effects can increase toxicity, including QT prolongation from erythromycin and infections, diarrhea or skin reactions from duvelisib.
What this interaction means in plain words
Duvelisib and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Erythromycin belongs to Anti Bacterial.
Why it happens
Mutual CYP3A4 inhibition, with erythromycin also inhibiting P-glycoprotein, reduces clearance of both drugs.
What to do
Monitor for erythromycin toxicity and duvelisib adverse effects. Reduce the dose of the sensitive CYP3A4 substrate or choose an alternative antibiotic if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Erythromycin?
MediHelp rates the interaction as moderate. Duvelisib and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib is a CYP3A4 inhibitor and may increase erythromycin exposure, while erythromycin may in turn raise duvelisib levels through CYP3A4 and P-gp inhibition. Both effects can increase toxicity, including QT prolongation from erythromycin and infections, diarrhea or skin reactions from duvelisib.
How serious is the interaction between Duvelisib and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erythromycin toxicity and duvelisib adverse effects. Reduce the dose of the sensitive CYP3A4 substrate or choose an alternative antibiotic if possible.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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