Drug interactions
Duvelisib + Fluticasone-salmeterol
Severity: Moderate
Duvelisib and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and can raise salmeterol and fluticasone concentrations. Higher salmeterol exposure may cause tachycardia, tremor, hypokalemia and QT prolongation, and higher fluticasone exposure may cause systemic corticosteroid effects.
What this interaction means in plain words
Duvelisib and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Inhibition of CYP3A4 by duvelisib reduces the metabolism of salmeterol and fluticasone.
What to do
Monitor heart rate, palpitations, potassium and signs of corticosteroid excess. Consider reducing the dose of the inhaled combination if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Duvelisib and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and can raise salmeterol and fluticasone concentrations. Higher salmeterol exposure may cause tachycardia, tremor, hypokalemia and QT prolongation, and higher fluticasone exposure may cause systemic corticosteroid effects.
How serious is the interaction between Duvelisib and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, palpitations, potassium and signs of corticosteroid excess. Consider reducing the dose of the inhaled combination if adverse effects appear.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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