Drug interactions
Duvelisib + Irinotecan
Severity: Moderate
Duvelisib and Irinotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and raises exposure to sensitive substrates. Inhibition of irinotecan's CYP3A4 metabolism may increase SN-38 formation and toxicity, while duvelisib also causes diarrhoea and cytopenias.
What this interaction means in plain words
Duvelisib and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Irinotecan belongs to Oncology.
Why it happens
CYP3A4 inhibition by duvelisib reduces irinotecan clearance.
What to do
Monitor for severe diarrhoea and neutropenia, and consider reducing the irinotecan dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Irinotecan?
MediHelp rates the interaction as moderate. Duvelisib and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and raises exposure to sensitive substrates. Inhibition of irinotecan's CYP3A4 metabolism may increase SN-38 formation and toxicity, while duvelisib also causes diarrhoea and cytopenias.
How serious is the interaction between Duvelisib and Irinotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for severe diarrhoea and neutropenia, and consider reducing the irinotecan dose.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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