Drug interactions
Duvelisib + Isosorbide dinitrate
Severity: Minor
Duvelisib and Isosorbide dinitrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and raises exposure to sensitive CYP3A4 substrates. Isosorbide dinitrate is not primarily cleared by CYP3A4, so a clinically important rise in nitrate levels is unlikely.
What this interaction means in plain words
Duvelisib and Isosorbide dinitrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Duvelisib belongs to Oncology; Isosorbide dinitrate belongs to Cardiovascular.
Why it happens
Duvelisib inhibits CYP3A4, a minor pathway for isosorbide dinitrate metabolism.
What to do
No routine dose adjustment is needed. Check for hypotension and headache when duvelisib is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide dinitrate Major
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Isosorbide dinitrate?
MediHelp rates the interaction as minor. Duvelisib and Isosorbide dinitrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Duvelisib inhibits CYP3A4 and raises exposure to sensitive CYP3A4 substrates. Isosorbide dinitrate is not primarily cleared by CYP3A4, so a clinically important rise in nitrate levels is unlikely.
How serious is the interaction between Duvelisib and Isosorbide dinitrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed. Check for hypotension and headache when duvelisib is started.
What other medicines interact with Isosorbide dinitrate?
MediHelp also lists interactions of Isosorbide dinitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide dinitrate page.
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