Drug interactions
Duvelisib + Lidocaine
Severity: Moderate
Duvelisib and Lidocaine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib is a CYP3A4 inhibitor that raises exposure to sensitive CYP3A4 substrates. Lidocaine is partly cleared by CYP3A4, so systemic levels may increase and raise the risk of toxicity affecting the CNS and heart. The effect is mainly relevant for systemic lidocaine.
What this interaction means in plain words
Duvelisib and Lidocaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Lidocaine belongs to Cardiovascular.
Why it happens
Duvelisib inhibits CYP3A4, reducing the hepatic metabolism of lidocaine.
What to do
With systemic lidocaine, consider a lower dose and monitor for CNS and cardiac toxicity. Topical or single local use usually requires no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Lidocaine?
MediHelp rates the interaction as moderate. Duvelisib and Lidocaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib is a CYP3A4 inhibitor that raises exposure to sensitive CYP3A4 substrates. Lidocaine is partly cleared by CYP3A4, so systemic levels may increase and raise the risk of toxicity affecting the CNS and heart. The effect is mainly relevant for systemic lidocaine.
How serious is the interaction between Duvelisib and Lidocaine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic lidocaine, consider a lower dose and monitor for CNS and cardiac toxicity. Topical or single local use usually requires no change.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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