Drug interactions
Duvelisib + Nifedipine
Severity: Moderate
Duvelisib and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and increases exposure to sensitive substrates. Nifedipine levels may rise, increasing the risk of hypotension, flushing, headache and peripheral edema.
What this interaction means in plain words
Duvelisib and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Nifedipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 by duvelisib reduces nifedipine metabolism.
What to do
Monitor blood pressure and heart rate and consider a lower nifedipine dose. Watch for edema and symptomatic hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Duvelisib and Nifedipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Nifedipine
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Nifedipine?
MediHelp rates the interaction as moderate. Duvelisib and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and increases exposure to sensitive substrates. Nifedipine levels may rise, increasing the risk of hypotension, flushing, headache and peripheral edema.
How serious is the interaction between Duvelisib and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and consider a lower nifedipine dose. Watch for edema and symptomatic hypotension.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
