Drug interactions
Duvelisib + Nilotinib
Severity: Major
Duvelisib and Nilotinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and can raise exposure to nilotinib, which is a CYP3A4 substrate with dose-related QT prolongation. Higher nilotinib levels could increase the risk of QT prolongation and other toxicities.
What this interaction means in plain words
Duvelisib and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duvelisib belongs to Oncology; Nilotinib belongs to Oncology.
Why it happens
Duvelisib inhibits CYP3A4, reducing the metabolic clearance of nilotinib.
What to do
Avoid the combination if possible, or consider reducing the nilotinib dose. Obtain an ECG and monitor electrolytes and for signs of nilotinib toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Nilotinib?
MediHelp rates the interaction as major. Duvelisib and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Duvelisib inhibits CYP3A4 and can raise exposure to nilotinib, which is a CYP3A4 substrate with dose-related QT prolongation. Higher nilotinib levels could increase the risk of QT prolongation and other toxicities.
How serious is the interaction between Duvelisib and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or consider reducing the nilotinib dose. Obtain an ECG and monitor electrolytes and for signs of nilotinib toxicity.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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