Drug interactions
Duvelisib + Pazopanib
Severity: Moderate
Duvelisib and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and may raise pazopanib exposure, increasing risks such as hepatotoxicity, hypertension and QT prolongation.
What this interaction means in plain words
Duvelisib and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Pazopanib belongs to Oncology.
Why it happens
Duvelisib inhibits CYP3A4-mediated metabolism of pazopanib.
What to do
Monitor liver enzymes, blood pressure and ECG, and reduce the pazopanib dose if toxicity appears. Consider an alternative if toxicity is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Pazopanib?
MediHelp rates the interaction as moderate. Duvelisib and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and may raise pazopanib exposure, increasing risks such as hepatotoxicity, hypertension and QT prolongation.
How serious is the interaction between Duvelisib and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes, blood pressure and ECG, and reduce the pazopanib dose if toxicity appears. Consider an alternative if toxicity is a concern.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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