Drug interactions
Duvelisib + Pimavanserin
Severity: Moderate
Duvelisib and Pimavanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and raises exposure of sensitive CYP3A substrates. Pimavanserin levels may increase, heightening the risk of dose-related adverse effects including QT prolongation.
What this interaction means in plain words
Duvelisib and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Pimavanserin belongs to Central Nervous System.
Why it happens
Duvelisib inhibits CYP3A4, reducing pimavanserin clearance.
What to do
Consider reducing the pimavanserin dose and monitor for QT prolongation, sedation and other adverse effects while duvelisib is co-administered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Pimavanserin?
MediHelp rates the interaction as moderate. Duvelisib and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and raises exposure of sensitive CYP3A substrates. Pimavanserin levels may increase, heightening the risk of dose-related adverse effects including QT prolongation.
How serious is the interaction between Duvelisib and Pimavanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the pimavanserin dose and monitor for QT prolongation, sedation and other adverse effects while duvelisib is co-administered.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
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