Drug interactions
Duvelisib + Praziquantel
Severity: Moderate
Duvelisib and Praziquantel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib is a CYP3A4 substrate and inhibitor, so it would be expected to raise rather than lower praziquantel levels. The clinical effect is uncertain but may increase praziquantel adverse effects such as dizziness.
What this interaction means in plain words
Duvelisib and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Praziquantel belongs to Anti Parasitic.
Why it happens
CYP3A4 inhibition by duvelisib may decrease praziquantel metabolism; this is predicted rather than established.
What to do
Monitor for dizziness, drowsiness and gastrointestinal effects after praziquantel dosing. Advise against driving on treatment days.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Praziquantel?
MediHelp rates the interaction as moderate. Duvelisib and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib is a CYP3A4 substrate and inhibitor, so it would be expected to raise rather than lower praziquantel levels. The clinical effect is uncertain but may increase praziquantel adverse effects such as dizziness.
How serious is the interaction between Duvelisib and Praziquantel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, drowsiness and gastrointestinal effects after praziquantel dosing. Advise against driving on treatment days.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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