Drug interactions
Duvelisib + Quinine
Severity: Moderate
Duvelisib and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and can increase quinine concentrations, raising the risk of cinchonism, hypoglycemia and QT prolongation. Quinine may also modestly raise duvelisib exposure through P-gp inhibition.
What this interaction means in plain words
Duvelisib and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Quinine belongs to Anti Parasitic.
Why it happens
Duvelisib inhibits CYP3A4 metabolism of quinine, and quinine inhibits P-gp efflux of duvelisib.
What to do
Monitor for quinine toxicity and consider ECG monitoring or a lower quinine dose. Watch for duvelisib adverse effects such as diarrhea, rash and infections.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Quinine?
MediHelp rates the interaction as moderate. Duvelisib and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and can increase quinine concentrations, raising the risk of cinchonism, hypoglycemia and QT prolongation. Quinine may also modestly raise duvelisib exposure through P-gp inhibition.
How serious is the interaction between Duvelisib and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for quinine toxicity and consider ECG monitoring or a lower quinine dose. Watch for duvelisib adverse effects such as diarrhea, rash and infections.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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