Drug interactions
Duvelisib + Safinamide
Severity: Minor
Duvelisib and Safinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide may inhibit BCRP, which could raise duvelisib exposure. Higher duvelisib levels may increase toxicities such as diarrhea, infection and cutaneous reactions.
What this interaction means in plain words
Duvelisib and Safinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Duvelisib belongs to Oncology; Safinamide belongs to Central Nervous System.
Why it happens
Inhibition of BCRP efflux may increase duvelisib absorption.
What to do
Monitor for duvelisib toxicity, including diarrhea, rash and infection. Interrupt or reduce the duvelisib dose according to its labeling if toxicity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Safinamide?
MediHelp rates the interaction as minor. Duvelisib and Safinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Safinamide may inhibit BCRP, which could raise duvelisib exposure. Higher duvelisib levels may increase toxicities such as diarrhea, infection and cutaneous reactions.
How serious is the interaction between Duvelisib and Safinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duvelisib toxicity, including diarrhea, rash and infection. Interrupt or reduce the duvelisib dose according to its labeling if toxicity occurs.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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