Drug interactions
Duvelisib + Salmeterol
Severity: Moderate
Duvelisib and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and may increase salmeterol exposure. This may enhance cardiovascular effects such as tachycardia, QT prolongation and hypokalemia.
What this interaction means in plain words
Duvelisib and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Salmeterol belongs to Respiratory.
Why it happens
Inhibition of CYP3A4-mediated salmeterol metabolism by duvelisib.
What to do
Monitor heart rate, potassium and ECG if cardiac risk is present, and consider an alternative long-acting beta-agonist not reliant on CYP3A4. Counsel the patient to report palpitations or tremor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Salmeterol?
MediHelp rates the interaction as moderate. Duvelisib and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and may increase salmeterol exposure. This may enhance cardiovascular effects such as tachycardia, QT prolongation and hypokalemia.
How serious is the interaction between Duvelisib and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, potassium and ECG if cardiac risk is present, and consider an alternative long-acting beta-agonist not reliant on CYP3A4. Counsel the patient to report palpitations or tremor.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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