Drug interactions
Duvelisib + Tolterodine
Severity: Moderate
Duvelisib and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and can raise exposure to CYP3A substrates. Tolterodine is mainly cleared via CYP2D6, but in CYP2D6 poor metabolizers CYP3A4 is the main route, so levels and anticholinergic effects could rise and the QT effect of tolterodine may matter.
What this interaction means in plain words
Duvelisib and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Tolterodine belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4-mediated tolterodine metabolism by duvelisib.
What to do
Monitor for anticholinergic adverse effects and consider reducing the tolterodine dose, particularly in known CYP2D6 poor metabolizers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Tolterodine?
MediHelp rates the interaction as moderate. Duvelisib and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and can raise exposure to CYP3A substrates. Tolterodine is mainly cleared via CYP2D6, but in CYP2D6 poor metabolizers CYP3A4 is the main route, so levels and anticholinergic effects could rise and the QT effect of tolterodine may matter.
How serious is the interaction between Duvelisib and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and consider reducing the tolterodine dose, particularly in known CYP2D6 poor metabolizers.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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