Drug interactions
Duvelisib + Trastuzumab
Severity: Moderate
Duvelisib and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib is associated with neutropenia and serious infections, and trastuzumab with myelosuppressive therapy has been linked to more neutropenia. Together they may increase infection risk.
What this interaction means in plain words
Duvelisib and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive myelosuppressive and immunosuppressive effects.
What to do
Monitor blood counts and infection signs, and continue antimicrobial prophylaxis as recommended for duvelisib. Interrupt or reduce duvelisib for severe neutropenia or infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Trastuzumab?
MediHelp rates the interaction as moderate. Duvelisib and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib is associated with neutropenia and serious infections, and trastuzumab with myelosuppressive therapy has been linked to more neutropenia. Together they may increase infection risk.
How serious is the interaction between Duvelisib and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and infection signs, and continue antimicrobial prophylaxis as recommended for duvelisib. Interrupt or reduce duvelisib for severe neutropenia or infection.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
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