Drug interactions
Duvelisib + Vincristine
Severity: Major
Duvelisib and Vincristine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and increases exposure to sensitive CYP3A4 substrates. Higher vincristine levels may increase neurotoxicity and gastrointestinal toxicity such as constipation or ileus.
What this interaction means in plain words
Duvelisib and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duvelisib belongs to Oncology; Vincristine belongs to Oncology.
Why it happens
Duvelisib inhibits CYP3A4, reducing vincristine clearance.
What to do
Monitor for neuropathy, constipation and myelosuppression, and consider reducing the vincristine dose. Prefer an alternative to duvelisib if feasible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Vincristine?
MediHelp rates the interaction as major. Duvelisib and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Duvelisib inhibits CYP3A4 and increases exposure to sensitive CYP3A4 substrates. Higher vincristine levels may increase neurotoxicity and gastrointestinal toxicity such as constipation or ileus.
How serious is the interaction between Duvelisib and Vincristine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy, constipation and myelosuppression, and consider reducing the vincristine dose. Prefer an alternative to duvelisib if feasible.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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