Drug interactions
Echinacea + Rilonacept
Severity: Minor
Echinacea and Rilonacept: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Echinacea may theoretically stimulate inflammatory pathways and oppose the interleukin-1 blockade of rilonacept. Control of cryopyrin-associated periodic syndromes could be reduced. No clinical evidence supports this.
What this interaction means in plain words
Echinacea and Rilonacept have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Echinacea belongs to Gastrointestinal Tract; Rilonacept belongs to Miscellaneous.
Why it happens
Theoretical pharmacodynamic opposition between immune stimulation and interleukin-1 inhibition.
What to do
Discourage echinacea use in patients on rilonacept. Monitor symptoms and inflammatory markers if it is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Echinacea
- Alefacept + Echinacea Moderate
- Antithymocyte globulin equine + Echinacea Moderate
- Antithymocyte globulin rabbit + Echinacea Moderate
- Azathioprine + Echinacea Moderate
- Basiliximab + Echinacea Moderate
- Cyclosporine + Echinacea Moderate
Other interactions of Rilonacept
Frequently asked questions
Can I take Echinacea with Rilonacept?
MediHelp rates the interaction as minor. Echinacea and Rilonacept have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Echinacea may theoretically stimulate inflammatory pathways and oppose the interleukin-1 blockade of rilonacept. Control of cryopyrin-associated periodic syndromes could be reduced. No clinical evidence supports this.
How serious is the interaction between Echinacea and Rilonacept?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discourage echinacea use in patients on rilonacept. Monitor symptoms and inflammatory markers if it is used.
What other medicines interact with Echinacea?
MediHelp also lists interactions of Echinacea with, for example, Alefacept, Antithymocyte globulin equine, Antithymocyte globulin rabbit. The full list is on the Echinacea page.
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