Drug interactions
Certolizumab pegol + Rilonacept
Severity: Major
Certolizumab pegol and Rilonacept: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block cytokines (TNF and IL-1) central to host defence. Using them together raises the risk of serious infections. Labeling for IL-1 blockers advises against combining with TNF inhibitors.
What this interaction means in plain words
Certolizumab pegol and Rilonacept can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Certolizumab pegol belongs to Musculoskeletal; Rilonacept belongs to Miscellaneous.
Why it happens
Additive immunosuppression through TNF and IL-1 blockade.
What to do
Avoid concurrent use and choose one agent. If combined, monitor closely for signs of infection and stop at the first serious infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Other interactions of Rilonacept
- Adalimumab + Rilonacept Major
- Anakinra + Rilonacept Major
- Baricitinib + Rilonacept Major
- Cyclosporin + Rilonacept Major
- Etanercept + Rilonacept Major
- Golimumab + Rilonacept Major
Frequently asked questions
Can I take Certolizumab pegol with Rilonacept?
MediHelp rates the interaction as major. Certolizumab pegol and Rilonacept can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs block cytokines (TNF and IL-1) central to host defence. Using them together raises the risk of serious infections. Labeling for IL-1 blockers advises against combining with TNF inhibitors.
How serious is the interaction between Certolizumab pegol and Rilonacept?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose one agent. If combined, monitor closely for signs of infection and stop at the first serious infection.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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