Drug interactions
Cyclosporin + Rilonacept
Severity: Major
Cyclosporin and Rilonacept: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents suppress immune function, and using them together may raise the risk of serious infections. Rilonacept blocks interleukin-1 signalling while cyclosporine inhibits T-cell activation.
What this interaction means in plain words
Cyclosporin and Rilonacept can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Rilonacept belongs to Miscellaneous.
Why it happens
Additive immunosuppression through IL-1 blockade and calcineurin inhibition.
What to do
Avoid the combination where possible; if both are needed, monitor closely for signs of infection and treat promptly. Screen for latent infections such as tuberculosis beforehand.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Rilonacept
- Adalimumab + Rilonacept Major
- Anakinra + Rilonacept Major
- Baricitinib + Rilonacept Major
- Certolizumab pegol + Rilonacept Major
- Etanercept + Rilonacept Major
- Golimumab + Rilonacept Major
Frequently asked questions
Can I take Cyclosporin with Rilonacept?
MediHelp rates the interaction as major. Cyclosporin and Rilonacept can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents suppress immune function, and using them together may raise the risk of serious infections. Rilonacept blocks interleukin-1 signalling while cyclosporine inhibits T-cell activation.
How serious is the interaction between Cyclosporin and Rilonacept?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if both are needed, monitor closely for signs of infection and treat promptly. Screen for latent infections such as tuberculosis beforehand.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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