Drug interactions
Echinacea + Sirolimus
Severity: Moderate
Echinacea and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Echinacea has immunostimulant properties that may oppose the intended immunosuppression with sirolimus. This could theoretically raise the risk of graft rejection or reduced efficacy.
What this interaction means in plain words
Echinacea and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Echinacea belongs to Gastrointestinal Tract; Sirolimus belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism through immune stimulation; the mechanism is not firmly established.
What to do
Advise transplant patients to avoid echinacea products; if used, monitor for signs of rejection and graft function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Echinacea
- Alefacept + Echinacea Moderate
- Antithymocyte globulin equine + Echinacea Moderate
- Antithymocyte globulin rabbit + Echinacea Moderate
- Azathioprine + Echinacea Moderate
- Basiliximab + Echinacea Moderate
- Cyclosporine + Echinacea Moderate
Frequently asked questions
Can I take Echinacea with Sirolimus?
MediHelp rates the interaction as moderate. Echinacea and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Echinacea has immunostimulant properties that may oppose the intended immunosuppression with sirolimus. This could theoretically raise the risk of graft rejection or reduced efficacy.
How serious is the interaction between Echinacea and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise transplant patients to avoid echinacea products; if used, monitor for signs of rejection and graft function.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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