Drug interactions
Edoxaban + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Major
Edoxaban and Elvitegravir / cobicistat / emtricitabine / tenofovir df: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits P-glycoprotein and can increase edoxaban exposure, raising bleeding risk. Tenofovir DF also needs renal monitoring, which matters for edoxaban clearance.
What this interaction means in plain words
Edoxaban and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Cobicistat inhibits P-glycoprotein (and CYP3A), increasing edoxaban absorption and reducing its clearance.
What to do
Prefer an alternative anticoagulant or regimen when feasible; otherwise monitor for bleeding and renal function, using the reduced edoxaban dose for DVT/PE.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as major. Edoxaban and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat inhibits P-glycoprotein and can increase edoxaban exposure, raising bleeding risk. Tenofovir DF also needs renal monitoring, which matters for edoxaban clearance.
How serious is the interaction between Edoxaban and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative anticoagulant or regimen when feasible; otherwise monitor for bleeding and renal function, using the reduced edoxaban dose for DVT/PE.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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