Drug interactions
Edoxaban + Erythromycin ethylsuccinate
Severity: Moderate
Edoxaban and Erythromycin ethylsuccinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin increases edoxaban exposure in pharmacokinetic studies through P-glycoprotein inhibition, which raises bleeding risk.
What this interaction means in plain words
Edoxaban and Erythromycin ethylsuccinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Erythromycin inhibits P-glycoprotein, reducing edoxaban efflux and clearance.
What to do
Reduce edoxaban to 30 mg daily for DVT/PE treatment; no adjustment is recommended for atrial fibrillation. Monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Erythromycin ethylsuccinate?
MediHelp rates the interaction as moderate. Edoxaban and Erythromycin ethylsuccinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin increases edoxaban exposure in pharmacokinetic studies through P-glycoprotein inhibition, which raises bleeding risk.
How serious is the interaction between Edoxaban and Erythromycin ethylsuccinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce edoxaban to 30 mg daily for DVT/PE treatment; no adjustment is recommended for atrial fibrillation. Monitor for bleeding.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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