Drug interactions
Edoxaban + Fish oil triglycerides
Severity: Moderate
Edoxaban and Fish oil triglycerides: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose omega-3 fatty acids may mildly impair platelet aggregation and prolong bleeding time. Combined with edoxaban, bleeding risk may increase slightly.
What this interaction means in plain words
Edoxaban and Fish oil triglycerides can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect on hemostasis from omega-3 antiplatelet activity and factor Xa inhibition.
What to do
Monitor for bleeding and reassess the need for fish oil, especially at high doses or with other antithrombotic drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Fish oil triglycerides?
MediHelp rates the interaction as moderate. Edoxaban and Fish oil triglycerides can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose omega-3 fatty acids may mildly impair platelet aggregation and prolong bleeding time. Combined with edoxaban, bleeding risk may increase slightly.
How serious is the interaction between Edoxaban and Fish oil triglycerides?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and reassess the need for fish oil, especially at high doses or with other antithrombotic drugs.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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