Drug interactions
Edoxaban + Glecaprevir / pibrentasvir
Severity: Moderate
Edoxaban and Glecaprevir / pibrentasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-gp and can increase edoxaban exposure, potentially increasing bleeding risk during the hepatitis C treatment course.
What this interaction means in plain words
Edoxaban and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of P-glycoprotein (and BCRP) increases edoxaban absorption.
What to do
Monitor for bleeding during the treatment course and consider an alternative anticoagulant if bleeding risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Edoxaban and Glecaprevir / pibrentasvir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as moderate. Edoxaban and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit P-gp and can increase edoxaban exposure, potentially increasing bleeding risk during the hepatitis C treatment course.
How serious is the interaction between Edoxaban and Glecaprevir / pibrentasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding during the treatment course and consider an alternative anticoagulant if bleeding risk is high.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
