Drug interactions
Edoxaban + Nefazodone
Severity: Moderate
Edoxaban and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone inhibits P-glycoprotein and could increase edoxaban exposure, raising bleeding risk. The interaction is mostly predicted from mechanism.
What this interaction means in plain words
Edoxaban and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nefazodone inhibits P-glycoprotein, reducing edoxaban efflux.
What to do
Monitor for bleeding and consider an alternative antidepressant, since nefazodone is rarely first-line.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Nefazodone?
MediHelp rates the interaction as moderate. Edoxaban and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone inhibits P-glycoprotein and could increase edoxaban exposure, raising bleeding risk. The interaction is mostly predicted from mechanism.
How serious is the interaction between Edoxaban and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider an alternative antidepressant, since nefazodone is rarely first-line.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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