Drug interactions
Edoxaban + Progesterone micronized
Severity: Minor
Edoxaban and Progesterone micronized: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progesterone is only a weak P-gp inhibitor in vitro, and no meaningful increase in edoxaban exposure is established at usual doses. The legacy severity is not supported by clinical data.
What this interaction means in plain words
Edoxaban and Progesterone micronized have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak P-glycoprotein inhibition; no clinically established effect on edoxaban.
What to do
No dose change is needed; monitor for bleeding as for any edoxaban patient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Progesterone micronized?
MediHelp rates the interaction as minor. Edoxaban and Progesterone micronized have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progesterone is only a weak P-gp inhibitor in vitro, and no meaningful increase in edoxaban exposure is established at usual doses. The legacy severity is not supported by clinical data.
How serious is the interaction between Edoxaban and Progesterone micronized?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for bleeding as for any edoxaban patient.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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