Drug interactions
edoxaban + rifampin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↓ edoxaban levels → thrombosis risk.
Mechanism of action
P-gp induction.
Clinical management
Avoid combination.
Drug reference
References
Frequently asked questions
Can I take edoxaban with rifampin?
The interaction is rated: Major. ↓ edoxaban levels → thrombosis risk.
How serious is the interaction between edoxaban and rifampin?
The interaction is rated: Major. Evidence level: High.
How is the interaction between edoxaban and rifampin managed?
Avoid combination.
Why do edoxaban and rifampin interact?
P-gp induction.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.