Drug interactions
Edoxaban + Salsalate
Severity: Moderate
Edoxaban and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a nonacetylated salicylate that can impair platelet function and irritate the gastrointestinal mucosa. Taken with edoxaban, it may raise the risk of clinically relevant bleeding, particularly gastrointestinal bleeding.
What this interaction means in plain words
Edoxaban and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect: factor Xa inhibition combined with salicylate-related platelet inhibition and mucosal injury.
What to do
Avoid regular use where an alternative analgesic such as paracetamol is suitable; otherwise monitor for bleeding and hemoglobin and consider gastroprotection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Edoxaban and Salsalate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Salsalate?
MediHelp rates the interaction as moderate. Edoxaban and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a nonacetylated salicylate that can impair platelet function and irritate the gastrointestinal mucosa. Taken with edoxaban, it may raise the risk of clinically relevant bleeding, particularly gastrointestinal bleeding.
How serious is the interaction between Edoxaban and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use where an alternative analgesic such as paracetamol is suitable; otherwise monitor for bleeding and hemoglobin and consider gastroprotection.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
