Drug interactions
Edoxaban + Saquinavir
Severity: Major
Edoxaban and Saquinavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir, usually boosted with ritonavir, inhibits P-gp and can raise edoxaban levels, increasing the risk of bleeding.
What this interaction means in plain words
Edoxaban and Saquinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of P-glycoprotein efflux increases edoxaban absorption and reduces its clearance.
What to do
Prefer an alternative anticoagulant or antiretroviral. If coadministered, monitor closely for bleeding and consider labeled dose reduction for the indication.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Saquinavir?
MediHelp rates the interaction as major. Edoxaban and Saquinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Saquinavir, usually boosted with ritonavir, inhibits P-gp and can raise edoxaban levels, increasing the risk of bleeding.
How serious is the interaction between Edoxaban and Saquinavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative anticoagulant or antiretroviral. If coadministered, monitor closely for bleeding and consider labeled dose reduction for the indication.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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