Drug interactions
Edoxaban + Ulipristal
Severity: Minor
Edoxaban and Ulipristal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ulipristal is a P-gp inhibitor and may raise edoxaban levels, but it is typically given as a single dose, so the effect is brief and probably small.
What this interaction means in plain words
Edoxaban and Ulipristal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible P-glycoprotein inhibition increasing edoxaban absorption.
What to do
No dose change is generally needed; be aware of bleeding signs after the dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Ulipristal?
MediHelp rates the interaction as minor. Edoxaban and Ulipristal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ulipristal is a P-gp inhibitor and may raise edoxaban levels, but it is typically given as a single dose, so the effect is brief and probably small.
How serious is the interaction between Edoxaban and Ulipristal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; be aware of bleeding signs after the dose.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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