Drug interactions
Edoxaban + Vorapaxar
Severity: Major
Edoxaban and Vorapaxar: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorapaxar blocks the PAR-1 platelet thrombin receptor, and edoxaban inhibits factor Xa. Used together they substantially increase the risk of bleeding, including serious bleeding, and vorapaxar has a very long duration of effect.
What this interaction means in plain words
Edoxaban and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic effect of anticoagulation and platelet PAR-1 antagonism.
What to do
Avoid the combination where possible, and weigh the bleeding risk carefully before using both. If used, monitor closely for bleeding and reassess the need regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Vorapaxar?
MediHelp rates the interaction as major. Edoxaban and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vorapaxar blocks the PAR-1 platelet thrombin receptor, and edoxaban inhibits factor Xa. Used together they substantially increase the risk of bleeding, including serious bleeding, and vorapaxar has a very long duration of effect.
How serious is the interaction between Edoxaban and Vorapaxar?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, and weigh the bleeding risk carefully before using both. If used, monitor closely for bleeding and reassess the need regularly.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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