Drug interactions
Efavirenz + Eltrombopag
Severity: Minor
Efavirenz and Eltrombopag: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The mechanism proposed for this pair is unclear. Efavirenz is not a clinically important CYP2C9 inhibitor, and it is more often an inducer, so a significant rise in eltrombopag exposure is not well supported.
What this interaction means in plain words
Efavirenz and Eltrombopag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Efavirenz belongs to Anti Virals; Eltrombopag belongs to Miscellaneous.
Why it happens
No well-established mechanism; any effect would be indirect via enzyme induction.
What to do
No dose change is routinely needed. Monitor platelet counts and liver tests, since both drugs can affect hepatic function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Efavirenz with Eltrombopag?
MediHelp rates the interaction as minor. Efavirenz and Eltrombopag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The mechanism proposed for this pair is unclear. Efavirenz is not a clinically important CYP2C9 inhibitor, and it is more often an inducer, so a significant rise in eltrombopag exposure is not well supported.
How serious is the interaction between Efavirenz and Eltrombopag?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed. Monitor platelet counts and liver tests, since both drugs can affect hepatic function.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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