Drug interactions
Efavirenz + Eszopiclone
Severity: Minor
Efavirenz and Eszopiclone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may reduce eszopiclone levels, potentially weakening its hypnotic effect.
What this interaction means in plain words
Efavirenz and Eszopiclone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Efavirenz belongs to Anti Virals; Eszopiclone belongs to Central Nervous System.
Why it happens
Efavirenz induces CYP3A4, which metabolizes eszopiclone.
What to do
Monitor sleep response and adjust the eszopiclone dose if effect is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Eszopiclone
Frequently asked questions
Can I take Efavirenz with Eszopiclone?
MediHelp rates the interaction as minor. Efavirenz and Eszopiclone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Efavirenz may reduce eszopiclone levels, potentially weakening its hypnotic effect.
How serious is the interaction between Efavirenz and Eszopiclone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sleep response and adjust the eszopiclone dose if effect is inadequate.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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