Drug interactions
Efavirenz + Fluticasone-vilanterol
Severity: Moderate
Efavirenz and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz induces CYP3A4 and may lower the concentrations of fluticasone furoate and vilanterol, with a possible loss of effect. Efavirenz can also prolong the QT interval, but this is a minor concern at inhaled vilanterol doses.
What this interaction means in plain words
Efavirenz and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
CYP3A4 induction reduces exposure to the inhaled drugs, and efavirenz adds a small QT effect.
What to do
Monitor asthma or COPD control and consider a change of therapy if control worsens. Check ECG if other QT risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Efavirenz and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz induces CYP3A4 and may lower the concentrations of fluticasone furoate and vilanterol, with a possible loss of effect. Efavirenz can also prolong the QT interval, but this is a minor concern at inhaled vilanterol doses.
How serious is the interaction between Efavirenz and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma or COPD control and consider a change of therapy if control worsens. Check ECG if other QT risk factors exist.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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