Drug interactions
Efavirenz + Linagliptin-metformin
Severity: Moderate
Efavirenz and Linagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz is a CYP3A4 inducer and may lower linagliptin exposure, potentially reducing its glucose-lowering efficacy. Efavirenz-based regimens can also contribute to metabolic disturbances.
What this interaction means in plain words
Efavirenz and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Linagliptin-metformin belongs to Endocrine.
Why it happens
Induction of CYP3A4 (and P-glycoprotein) increases linagliptin clearance.
What to do
Monitor glycemic control and consider an alternative antidiabetic agent if control worsens; metformin is not meaningfully affected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Linagliptin-metformin?
MediHelp rates the interaction as moderate. Efavirenz and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz is a CYP3A4 inducer and may lower linagliptin exposure, potentially reducing its glucose-lowering efficacy. Efavirenz-based regimens can also contribute to metabolic disturbances.
How serious is the interaction between Efavirenz and Linagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and consider an alternative antidiabetic agent if control worsens; metformin is not meaningfully affected.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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