Drug interactions
Efavirenz + Methohexital
Severity: Moderate
Efavirenz and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz can cause sedation and dizziness, which may add to the CNS and respiratory depression of methohexital. Efavirenz may also induce barbiturate metabolism, but the clinical effect on a single anesthetic dose is minor.
What this interaction means in plain words
Efavirenz and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depression.
What to do
Titrate methohexital carefully and monitor airway, ventilation and sedation depth.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Methohexital
Frequently asked questions
Can I take Efavirenz with Methohexital?
MediHelp rates the interaction as moderate. Efavirenz and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz can cause sedation and dizziness, which may add to the CNS and respiratory depression of methohexital. Efavirenz may also induce barbiturate metabolism, but the clinical effect on a single anesthetic dose is minor.
How serious is the interaction between Efavirenz and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital carefully and monitor airway, ventilation and sedation depth.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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