Drug interactions
Efavirenz + Nicardipine
Severity: Moderate
Efavirenz and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may reduce nicardipine concentrations through induction of CYP3A4, which could weaken blood pressure or angina control. The effect is predicted from mechanism and related calcium channel blocker data.
What this interaction means in plain words
Efavirenz and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Nicardipine belongs to Cardiovascular.
Why it happens
Efavirenz induces CYP3A4, increasing the metabolism of nicardipine.
What to do
Monitor blood pressure and heart rate and titrate nicardipine to clinical effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Nicardipine
Frequently asked questions
Can I take Efavirenz with Nicardipine?
MediHelp rates the interaction as moderate. Efavirenz and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz may reduce nicardipine concentrations through induction of CYP3A4, which could weaken blood pressure or angina control. The effect is predicted from mechanism and related calcium channel blocker data.
How serious is the interaction between Efavirenz and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and titrate nicardipine to clinical effect.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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