Drug interactions
Efavirenz + Oliceridine
Severity: Moderate
Efavirenz and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz induces CYP3A4, which is a main route of oliceridine clearance, so oliceridine exposure and analgesic effect may fall. If efavirenz is later stopped, oliceridine levels may rise, increasing the risk of respiratory depression.
What this interaction means in plain words
Efavirenz and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Oliceridine belongs to Musculoskeletal.
Why it happens
Induction of CYP3A4 by efavirenz increases oliceridine metabolism.
What to do
Monitor analgesia and titrate oliceridine upward if needed. If efavirenz is discontinued, reduce the oliceridine dose and monitor for sedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Efavirenz and Oliceridine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Efavirenz with Oliceridine?
MediHelp rates the interaction as moderate. Efavirenz and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz induces CYP3A4, which is a main route of oliceridine clearance, so oliceridine exposure and analgesic effect may fall. If efavirenz is later stopped, oliceridine levels may rise, increasing the risk of respiratory depression.
How serious is the interaction between Efavirenz and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesia and titrate oliceridine upward if needed. If efavirenz is discontinued, reduce the oliceridine dose and monitor for sedation and respiratory depression.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
