Drug interactions
Efavirenz + Paricalcitol
Severity: Minor
Efavirenz and Paricalcitol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may increase CYP3A4-mediated metabolism of paricalcitol, which could lower its exposure. The effect is predicted rather than well documented and is probably modest.
What this interaction means in plain words
Efavirenz and Paricalcitol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Efavirenz belongs to Anti Virals; Paricalcitol belongs to Musculoskeletal.
Why it happens
Efavirenz induces CYP3A4, which contributes to paricalcitol clearance.
What to do
Monitor intact PTH, calcium and phosphate, and adjust the paricalcitol dose according to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Paricalcitol
- Carbamazepine + Paricalcitol Moderate
- Cholestyramine + Paricalcitol Moderate
- Clarithromycin + Paricalcitol Moderate
- Digoxin + Paricalcitol Moderate
- Ketoconazole + Paricalcitol Moderate
- Paricalcitol + Posaconazole Moderate
Frequently asked questions
Can I take Efavirenz with Paricalcitol?
MediHelp rates the interaction as minor. Efavirenz and Paricalcitol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Efavirenz may increase CYP3A4-mediated metabolism of paricalcitol, which could lower its exposure. The effect is predicted rather than well documented and is probably modest.
How serious is the interaction between Efavirenz and Paricalcitol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor intact PTH, calcium and phosphate, and adjust the paricalcitol dose according to response.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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