Drug interactions
Efavirenz + Ramelteon
Severity: Minor
Efavirenz and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ramelteon is metabolized mainly by CYP1A2, with minor CYP2C and CYP3A4 contributions, so an effect of efavirenz is not well characterized. Any exposure change is likely modest.
What this interaction means in plain words
Efavirenz and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Efavirenz belongs to Anti Virals; Ramelteon belongs to Central Nervous System.
Why it happens
Efavirenz may modestly alter minor CYP2C/CYP3A4 metabolism of ramelteon; the effect is not well established.
What to do
No routine adjustment is needed; monitor for changes in sleep response or sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Efavirenz with Ramelteon?
MediHelp rates the interaction as minor. Efavirenz and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ramelteon is metabolized mainly by CYP1A2, with minor CYP2C and CYP3A4 contributions, so an effect of efavirenz is not well characterized. Any exposure change is likely modest.
How serious is the interaction between Efavirenz and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for changes in sleep response or sedation.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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