Drug interactions
Efavirenz + Repaglinide
Severity: Moderate
Efavirenz and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz can induce CYP3A4 and may lower repaglinide concentrations, reducing glucose-lowering effect. Repaglinide is also metabolized by CYP2C8, so the magnitude is uncertain.
What this interaction means in plain words
Efavirenz and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Repaglinide belongs to Endocrine.
Why it happens
Efavirenz induces CYP3A4-mediated repaglinide metabolism.
What to do
Monitor blood glucose after starting or stopping efavirenz and adjust repaglinide dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Efavirenz with Repaglinide?
MediHelp rates the interaction as moderate. Efavirenz and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz can induce CYP3A4 and may lower repaglinide concentrations, reducing glucose-lowering effect. Repaglinide is also metabolized by CYP2C8, so the magnitude is uncertain.
How serious is the interaction between Efavirenz and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping efavirenz and adjust repaglinide dose as needed.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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