Drug interactions
Efavirenz + Ripretinib
Severity: Major
Efavirenz and Ripretinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may reduce ripretinib and its active metabolite exposure, potentially reducing efficacy in gastrointestinal stromal tumors.
What this interaction means in plain words
Efavirenz and Ripretinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Efavirenz belongs to Anti Virals; Ripretinib belongs to Oncology.
Why it happens
CYP3A4 induction by efavirenz accelerates ripretinib metabolism.
What to do
Avoid the combination if possible and use a non-inducing antiretroviral. If unavoidable, monitor tumor response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Ripretinib
Frequently asked questions
Can I take Efavirenz with Ripretinib?
MediHelp rates the interaction as major. Efavirenz and Ripretinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Efavirenz may reduce ripretinib and its active metabolite exposure, potentially reducing efficacy in gastrointestinal stromal tumors.
How serious is the interaction between Efavirenz and Ripretinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and use a non-inducing antiretroviral. If unavoidable, monitor tumor response.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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