Drug interactions
Enzalutamide + Ripretinib
Severity: Major
Enzalutamide and Ripretinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ripretinib and its active metabolite are CYP3A substrates, so strong inducers lower exposure. Enzalutamide may reduce ripretinib efficacy in GIST.
What this interaction means in plain words
Enzalutamide and Ripretinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Ripretinib belongs to Oncology.
Why it happens
Enzalutamide induces CYP3A4, increasing ripretinib and metabolite clearance.
What to do
Avoid coadministration with strong CYP3A inducers. If it cannot be avoided, monitor tumor response; labeling suggests ripretinib dose increase with strong inducers in some cases.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Ripretinib
- Amobarbital + Ripretinib Major
- Apalutamide + Ripretinib Major
- Carbamazepine + Ripretinib Major
- Efavirenz + Ripretinib Major
- Phenytoin + Ripretinib Major
- Ripretinib + Secobarbital Major
Frequently asked questions
Can I take Enzalutamide with Ripretinib?
MediHelp rates the interaction as major. Enzalutamide and Ripretinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ripretinib and its active metabolite are CYP3A substrates, so strong inducers lower exposure. Enzalutamide may reduce ripretinib efficacy in GIST.
How serious is the interaction between Enzalutamide and Ripretinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration with strong CYP3A inducers. If it cannot be avoided, monitor tumor response; labeling suggests ripretinib dose increase with strong inducers in some cases.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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